Effect of imidazole on ionophore-induced ocular hypertension

The effect of intraperitoneal injections of imidazole on the elevation of intraocular pressure produced by the topical application of the cation ionophores A23187 or X537A was studied in rabbits. Pretreatment with 200 mg./kg. imidazole completely inhibited the ocular hypertension induced by 1.0 percent A23187. The elevation of intraocular pressure produced by 0.5 percent X537A was not blocked by pretreatment with imidazole.