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Segmental analysis of computerized optic nerve head imaging
A J Lish1, J S Lustgarten, M J Dunn
1Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, U.S.A.
Journal of Glaucoma
|November 19, 2009
Summary
This study introduces a new segmental analysis for optic nerve head depth measurements from the Humphrey Retinal Analyzer. The method shows promising results with acceptable variability for clinical use.
Area of Science:
- Ophthalmology
- Medical Imaging
- Optic Nerve Head Analysis
Background:
- Computerized retinal topographic imaging systems provide detailed optic nerve head (ONH) depth data.
- Segmental analysis of ONH topography may offer more nuanced diagnostic information than global measurements.
Purpose of the Study:
- To evaluate a novel segmental analysis method for ONH depth data obtained from the Humphrey Retinal Analyzer.
- To assess the intraobserver, interimage, and interobserver variability of this new segmental analysis technique.
Main Methods:
- The optic nerve head was divided into five rectangular areas.
- Mean depth was calculated for each area.
- Statistical analysis was performed to determine variability (intraobserver, interimage, interobserver).
Main Results:
- Intraobserver variability ranged from +/-1.2 to +/-12.0 mum (median 4.6 mum).
- Interimage variability ranged from +/-3.0 to +/-30.8 mum (median 14.7 mum).
- Observer-to-observer variability was not statistically significant compared to subject variance.
Conclusions:
- The proposed segmental analysis method for Humphrey Retinal Analyzer data is a viable approach.
- The calculated variability suggests potential for clinical application in optic nerve head assessment.
- Further validation with the Heidelberg Retinal Tomograph is underway.
