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Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

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Segmental analysis of computerized optic nerve head imaging.

A J Lish¹, J S Lustgarten, M J Dunn

¹Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, U.S.A.

Journal of Glaucoma

|November 19, 2009

Summary

This summary is machine-generated.

This study introduces a new segmental analysis for optic nerve head depth measurements from the Humphrey Retinal Analyzer. The method shows promising results with acceptable variability for clinical use.

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Area of Science:

Ophthalmology
Medical Imaging
Optic Nerve Head Analysis

Background:

Computerized retinal topographic imaging systems provide detailed optic nerve head (ONH) depth data.
Segmental analysis of ONH topography may offer more nuanced diagnostic information than global measurements.

Purpose of the Study:

To evaluate a novel segmental analysis method for ONH depth data obtained from the Humphrey Retinal Analyzer.
To assess the intraobserver, interimage, and interobserver variability of this new segmental analysis technique.

Main Methods:

The optic nerve head was divided into five rectangular areas.
Mean depth was calculated for each area.
Statistical analysis was performed to determine variability (intraobserver, interimage, interobserver).

Main Results:

Intraobserver variability ranged from +/-1.2 to +/-12.0 mum (median 4.6 mum).
Interimage variability ranged from +/-3.0 to +/-30.8 mum (median 14.7 mum).
Observer-to-observer variability was not statistically significant compared to subject variance.

Conclusions:

The proposed segmental analysis method for Humphrey Retinal Analyzer data is a viable approach.
The calculated variability suggests potential for clinical application in optic nerve head assessment.
Further validation with the Heidelberg Retinal Tomograph is underway.