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Association between estimated pulse wave velocity and the risk of stroke in middle-aged men

Sae Young Jae1, Kevin S Heffernan2, Sudhir Kurl3

  • 1Department of Sport Science, University of Seoul, Seoul, Republic of Korea.

International Journal of Stroke : Official Journal of the International Stroke Society
|October 13, 2020
PubMed

Insights

Estimated pulse wave velocity (ePWV) is linked to a higher risk of stroke in middle-aged men. Higher ePWV independently predicts both ischemic and hemorrhagic stroke events.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Epidemiology

Background:

  • Increased aortic stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), is linked to cerebrovascular damage.
  • Aortic stiffness is a known predictor of cerebrovascular events.

Purpose of the Study:

  • To investigate the association between estimated pulse wave velocity (ePWV) and stroke risk.
  • To analyze stroke subtypes (ischemic and hemorrhagic) in relation to ePWV.

Main Methods:

  • Prospective cohort study of 2666 middle-aged men (42-61 years).
  • Median follow-up of 28 years.
  • Statistical analysis adjusted for risk factors, comparing ePWV quartiles.

Main Results:

  • 471 strokes occurred, including 397 ischemic and 94 hemorrhagic.
  • Higher ePWV quartiles were associated with increased stroke risk (HR 2.37).
  • Increased risk observed for both ischemic (HR 2.23) and hemorrhagic stroke (HR 3.57).

Conclusions:

  • Estimated pulse wave velocity (ePWV) is an independent predictor of stroke.
  • ePWV is associated with increased risk of stroke and its subtypes in middle-aged men.
Abstract

Keywords:
Vascular stiffnessblood pressurecerebrovascularpulse wave velocity

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