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Immunoregulation in aging.

S Antonaci, E Jirillo, L Bonomo

    Diagnostic and Clinical Immunology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Immune system aging (senescence) impairs T and B cell responses. Factors like soluble suppressors and increased lymphocyte membrane viscosity contribute to reduced immune function in the elderly.

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    Area of Science:

    • Immunology
    • Gerontology
    • Cell Biology

    Background:

    • Immune system senescence leads to decreased functional capacities of lymphoid cells.
    • T and B cell-mediated responses and T-B regulation are reduced in aging.
    • Lymphocyte proportions remain similar in the elderly, suggesting intrinsic or extrinsic factors cause impaired immunoresponsiveness.

    Purpose of the Study:

    • To investigate the factors contributing to the decline of immune function in aged individuals.
    • To understand the role of intracellular/extracellular factors in impaired immunoresponsiveness.
    • To explore potential therapeutic approaches for age-related immune decline.

    Main Methods:

    • Review of existing evidence on immune senescence.
    • Analysis of factors affecting T and B cell responses in the elderly.

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  • Consideration of lymphocyte membrane microviscosity changes.

    • Main Results:

    • Evidence suggests a reduction in T and B cell-mediated responses.
    • Soluble suppressive factors and decreased LK production are implicated in immune decline.
    • Increased lymphocyte membrane microviscosity is observed in the elderly.

    Conclusions:

    • Immune senescence is multifactorial, involving reduced T and B cell function.
    • Soluble suppressors and altered lymphocyte membrane properties are key contributors to impaired immunity.
    • A multifactorial therapeutic strategy is suggested for correcting immune deficits in aging individuals.