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Updated: Dec 6, 2025
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
9.1K
Is hypervascular papillary renal cell carcinoma present?
Tatsuya Yamamoto1, Amori Gulanbar2, Kuniyoshi Hayashi3
1Department of Diagnostic Radiology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. yamatatu_01eik@yahoo.co.jp.
Abdominal Radiology (New York)
|October 13, 2020
Summary
Atypical papillary renal cell carcinoma (PRCC) shows higher CT attenuation values and microvessel density (MVD) compared to typical PRCC. A positive correlation exists between CT attenuation and MVD in PRCCs.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Papillary renal cell carcinoma (PRCC) is a subtype of kidney cancer.
- Atypical PRCC can exhibit imaging features mimicking other renal tumors.
- Understanding PRCC characteristics is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate atypical PRCC with early contrast enhancement and late washout.
- To correlate CT attenuation values in the corticomedullary phase (CMP) with endothelial cell counts in PRCCs.
Main Methods:
- Retrospective analysis of 22 pathologically confirmed PRCC cases (18 typical, 4 atypical).
- Measurement of CT attenuation values in the CMP and assessment of microvessel density (MVD) using anti-ERG antibody staining.
- Statistical comparison of CT values and MVD between typical and atypical PRCCs; correlation analysis between CT attenuation and MVD.
Main Results:
- Atypical PRCC demonstrated significantly higher mean CT attenuation values and MVD compared to typical PRCC.
- A weak positive correlation was observed between CT attenuation values and MVD in PRCCs.
Conclusions:
- Atypical PRCC can present with enhanced contrast patterns similar to clear cell renal cell carcinoma.
- A positive correlation between CMP CT attenuation values and vascular endothelial cell count in PRCCs was confirmed.
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