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Updated: Dec 6, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Synthesis and Encapsulation of Uniform Star-Shaped Block-Macromolecules
Kevin A Waibel1, Dafni Moatsou2, Michael A R Meier1,2
1Laboratory of Applied Chemistry, Institute of Biological and Chemical Systems - Functional Material Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Abstract:
Linear uniform oligomers synthesized via a two-step iterative cycle are postmodified with uniform octaethylene glycol monomethyl ether and finally coupled via azide-alkyne cycloaddition to yield uniform star-shaped block macromolecules with a mass ranging from 10 to 14 kDa. Each of the molecules is carefully characterized by NMR, electrospray ionization mass spectrometry (ESI-MS), and size exclusion chromatography (SEC) to underline their purity as well as their uniformity. The obtained star-shaped macromolecules are investigated in their ability to encapsulate dye molecules by carrying out qualitative solid-liquid phase transfer experiments.
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