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Updated: Dec 6, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Mediated Hydroacylation of Azobenzenes with α-Keto Acids
Jingya Yang1, Menghui Song1, Hongyan Zhou1,2
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Abstract:
A visible-light-mediated protocol for the hydroacylation of azobenzenes with α-keto acids has been developed. In the absence of any catalyst or additive, decarboxylative hydroacylation proceeded smoothly under visible-light irradiation at room temperature. A wide range of azobenzenes and α-keto acids were well-tolerated and afforded hydroacylation products in high to excellent yields. Preliminary investigations indicated that photoactive azobenzenes absorb visible light to enable the transformation.
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