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Modulation of human ovarian function by melatonin.

Seema Rai1, Hindole Ghosh2

  • 1Department of Zoology, Guru Ghasidas Vishwavidylaya, Bilaspur, Chhattisgarh, India, seemarai.72@ggu.ac.in.

Frontiers in Bioscience (Elite Edition)
|October 13, 2020
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Summary
This summary is machine-generated.

Melatonin, a key hormone, regulates crucial ovarian functions like egg development and ovulation. This hormone enhances egg quality, improving in vitro fertilization (IVF) success rates for female fertility.

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Area of Science:

  • Reproductive Endocrinology
  • Chronobiology

Background:

  • Melatonin, a pineal gland hormone, influences the female reproductive system.
  • Mammals, including humans, utilize MT1 and MT2 melatonin receptor subtypes in ovarian tissues.

Purpose of the Study:

  • To review the multifaceted roles of melatonin in female reproductive functions.
  • To elucidate the mechanisms of melatonin action via its receptors in the ovary.

Main Methods:

  • Literature review of studies on melatonin and ovarian function.
  • Analysis of research on melatonin receptor subtypes (MT1, MT2) in the human ovary.

Main Results:

  • Melatonin regulates folliculogenesis, oocyte quality, ovulation, and luteal function.
  • It impacts sex steroid receptor gene expression and ovarian steroidogenesis.
  • Melatonin enhances oocyte quality, increasing in vitro fertilization (IVF) success.

Conclusions:

  • Melatonin plays a central role in female fertility.
  • Understanding melatonin's actions is crucial for reproductive health and assisted reproductive technologies.