From genoprotection to rejuvenation
1Frontiers in Bioscience Research Institute in Aging and Cancer, 16471 Scientific Way, Irvine CA 92618, fbs@bioscience.org.
Frontiers in Bioscience (Landmark Edition)
|October 13, 2020
Summary
Strategies to combat aging involve interventions targeting nutrient sensors like AMPK and mTOR. These approaches, including dietary changes and NAD+ precursors, can extend lifespan and healthspan, potentially reversing aging signs.
Area of Science:
- Gerontology and cellular aging research.
- Molecular mechanisms of aging and longevity.
Background:
- Aging is characterized by impaired signaling pathways and reduced cellular functions.
- Key nutrient-sensing pathways (AMPK, mTOR, IIS, sirtuins, NFkB, FOXO) are central to aging processes.
Purpose of the Study:
- To review current anti-aging strategies and their impact on lifespan and healthspan.
- To explore interventions targeting cellular aging and tissue homeostasis.
Main Methods:
- Review of dietary, genetic, and pharmacological interventions.
- Analysis of molecular pathways and cellular processes involved in aging.
- Examination of emerging anti-aging technologies.
Main Results:
- Calorie restriction, dietary changes, and compounds like NAM, NMN, NR, NAD+, and hydrogen sulfide can delay aging.
- Senotherapeutics, senolytics, senomorphics, and anti-inflammaging strategies address age-related decline.
- Epigenetic reprogramming offers potential for reversing aging signs.
Conclusions:
- Multiple interventions targeting nutrient sensors and cellular functions can extend lifespan and healthspan.
- A combination of strategies, including senotherapeutics and epigenetic reprogramming, holds promise for combating aging.
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