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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Oct 24, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

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CircadiOmic medicine and aging.

Siamak Tabibzadeh1

  • 1Frontiers in Bioscience Research Institute in Aging and Cancer, 16471 Scientific Way, Irvine, CA 92618, United States.

Ageing Research Reviews
|August 14, 2021
PubMed
Summary

Circadian rhythms, or biological clocks, regulate bodily functions and are crucial for health. Disruptions to these rhythms are linked to aging and various diseases, highlighting the importance of circadiomics in medicine.

Area of Science:

  • Chronobiology
  • Genomics
  • Aging Research

Background:

  • Environmental cycles (daily, seasonal, annual) drive rhythmic biological processes across the biosphere.
  • Organisms possess internal biological clocks (circadiome) synchronized with these environmental cues.
  • Robustness of these biological rhythms is vital for cellular, tissue, and organ function.

Purpose of the Study:

  • To review current knowledge on circadiomics and its implications for health and aging.
  • To explore the role of biological timekeepers in responding to environmental cues.
  • To discuss the impact of circadian rhythm disruption on disease and aging.

Main Methods:

  • Literature review of recent advancements in circadiomics.
  • Analysis of the synchronization mechanisms of the circadiome.
Keywords:
AgingAging ClockCircadianEpigenetic Modifiers

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Related Experiment Videos

Last Updated: Oct 24, 2025

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  • Examination of the link between circadian rhythm misalignment and health outcomes.

    • Main Results:

    • Biological timekeepers exhibit precise clock-like machinery, responding to environmental cues across various timescales.
    • Mis-alignment of circadian rhythms predisposes individuals to aging, sleep disorders, cancer, diabetes, and neurodegenerative diseases.
    • Circadian and CircadiOmic medicine are emerging fields focused on understanding and treating rhythm-related health issues.

    Conclusions:

    • Circadiomics offers insights into health and aging by studying biological rhythms.
    • Maintaining circadian rhythm integrity is essential for preventing age-related diseases and promoting longevity.
    • Personalized medicine and geroprotection strategies can be advanced through understanding circadian disruptions.