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A novel nanoapatite delivery system enhances imatinib bioavailability by converting it to an amorphous form. This system shows comparable effectiveness and cytotoxicity to imatinib alone, indicating its potential for drug delivery.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Imatinib (IM) is a crucial drug for treating certain cancers.
  • Improving imatinib's bioavailability through enhanced dissolution rates is a significant challenge.
  • Amorphous forms of pharmaceutical agents often exhibit superior dissolution properties compared to crystalline forms.

Purpose of the Study:

  • To develop and characterize a nanoapatite-mediated delivery system for imatinib.
  • To investigate the physicochemical properties and drug-carrier interactions of the system.
  • To evaluate the cytotoxicity and effectiveness of the nanoapatite-imatinib system.

Main Methods:

  • Nanohydroxyapatite (nHAp) synthesized via co-precipitation.
  • Physicochemical characterization using XRPD, SEM-EDS, FT-IR, absorption spectroscopy, and DLS.
  • Conversion of crystalline imatinib to its amorphous form.
  • Cytotoxicity assessment on NI-1, L929, and D17 cell lines.

Main Results:

  • Synthesized nHAp consisted of nanosized, rod-shaped, highly crystalline particles.
  • Amorphous imatinib was successfully prepared and loaded onto nHAp.
  • SEM, absorption, and FT-IR confirmed imatinib-hydroxyapatite surface interactions.
  • The nanoapatite-imatinib system demonstrated comparable effectiveness and IC50 values to imatinib alone.
  • Increased cytotoxicity was observed at higher imatinib concentrations in the nano-system.

Conclusions:

  • A nanoapatite-mediated delivery system for imatinib was successfully developed.
  • The system facilitates the use of amorphous imatinib, potentially improving bioavailability.
  • The nano-delivery system maintains imatinib's therapeutic effectiveness and exhibits predictable cytotoxicity.
  • This approach offers a promising strategy for enhancing imatinib drug delivery.