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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Hemorheologic parameters in correlation to extracranial carotid artery disease in patients with acute cerebrovascular

H Lechner, K Niederkorn, H Suzuki

    European Neurology
    |January 1, 1987
    PubMed

    Insights

    High plasma viscosity indicates severe extracranial carotid artery disease (ECAD) in patients with acute cerebrovascular disorders (CVD). This finding helps identify patients needing closer monitoring during the acute phase.

    Area of Science:

    • Vascular Medicine
    • Neurology
    • Hematology

    Background:

    • Extracranial carotid artery disease (ECAD) is a significant risk factor for cerebrovascular disorders (CVD).
    • Hemorheologic parameters may correlate with the severity of ECAD.

    Purpose of the Study:

    • To investigate the relationship between hemorheologic parameters and the extent of ECAD in patients with acute CVD.
    • To identify potential indicators of severe ECAD.

    Main Methods:

    • Studied 120 patients with acute CVD and 67 controls.
    • Assessed hemorheologic parameters: hematocrit, fibrinogen, whole blood viscosity, plasma viscosity, and platelet aggregation.
    • Investigated carotid arteries using Duplex scanning to determine ECAD extent.

    Main Results:

    • Plasma viscosity was significantly elevated only in CVD patients with severe ECAD (stenosis >80% or occlusion).
    • No significant differences in other hemorheologic parameters were observed between patient groups and controls.
    • Elevated plasma viscosity differentiated severe ECAD from normal or minimally diseased carotids in acute CVD patients.

    Conclusions:

    • High plasma viscosity is a potential indicator of severe ECAD in patients experiencing acute cerebrovascular disorders.
    • Plasma viscosity measurement may aid in identifying high-risk CVD patients during the acute stage.

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