Related Experiment Video

Updated: Dec 6, 2025

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

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[COVID-19-related Cerebrovascular Disease and Vasculitis]

Yoshiki Yagita1

  • 1Department of Stroke Medicine, Kawasaki Medical School.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|October 14, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause cerebrovascular disease and vasculitis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may infect vascular cells, leading to inflammation and critical conditions.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Systemic complications of COVID-19 include cerebrovascular disease and vasculitis.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is implicated.
  • Vascular endothelial cell infection via angiotensin-converting enzyme 2 (ACE2) is a proposed mechanism.

Purpose of the Study:

  • To explore the link between COVID-19 and cerebrovascular/vasculitis complications.
  • To understand the underlying pathophysiological mechanisms.
  • To identify potential therapeutic strategies.

Main Methods:

  • Review of existing literature on COVID-19-related neurological and vascular complications.
  • Analysis of proposed mechanisms including viral entry via ACE2 and inflammatory pathways.
  • Correlation of cerebrovascular disease and vasculitis with severe COVID-19 systemic conditions.

Main Results:

  • COVID-19 is associated with increased risks of cerebrovascular disease and vasculitis.
  • SARS-CoV-2 infection of vascular endothelial cells is a key proposed mechanism.
  • Cytokine storm and thrombotic tendencies are linked to these complications.

Conclusions:

  • COVID-19 poses significant risks for cerebrovascular and vasculitis-related diseases.
  • Understanding the diverse pathophysiology is crucial for effective treatment.
  • Further research is needed to establish optimal therapeutic regimens for favorable outcomes.

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