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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
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Recent Advances in Antiinflammatory Material Design.

Eloïse Lebaudy1,2, Sylvie Fournel3, Philippe Lavalle1,2,4

  • 1Institut National de la Santé et de la Recherche Médicale, INSERM Unité 1121 Biomaterials and Bioengineering, 11 rue Humann, Strasbourg Cedex, 67085, France.

Advanced Healthcare Materials
|October 14, 2020
PubMed
Summary

Advanced biomaterials aim to reduce inflammation and infection associated with implants. Novel smart materials offer intelligent anti-inflammatory responses, improving tissue integration and regeneration.

Keywords:
anti-inflammatory material designsbiomaterialscoatingshydrogelsnanoparticles

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Implants and prostheses are crucial for tissue repair but risk infection and inflammation.
  • Current biomaterials often elicit adverse inflammatory responses, hindering integration.

Purpose of the Study:

  • To review recent advancements in anti-inflammatory biomaterials.
  • To highlight strategies for mitigating implant-associated inflammation and infection.
  • To discuss novel multifunctional and stimuli-responsive biomaterial systems.

Main Methods:

  • Development of hydrogels, nanoparticles, and polymer coatings.
  • Engineering of drug delivery systems for anti-inflammatory agents.
  • Creation of multifunctional systems for combined therapeutic effects.
  • Design of stimuli-responsive (pH, temperature) materials.

Main Results:

  • Various biomaterial strategies effectively reduce inflammatory responses.
  • Multifunctional systems address inflammation, infection, bone regeneration, and angiogenesis.
  • Stimuli-responsive materials show potential for targeted anti-inflammatory action.
  • Novel materials promise enhanced implant integration and tissue regeneration.

Conclusions:

  • Significant progress has been made in developing anti-inflammatory biomaterials.
  • Multifunctional and smart biomaterials offer promising solutions for clinical challenges.
  • Future research focuses on intelligent, responsive systems for improved patient outcomes.