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Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
252
Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations
Cory W Baumann1, Dongmin Kwak2,3, LaDora V Thompson3
1Ohio Musculoskeletal and Neurological Institute (OMNI) and Department of Biomedical Sciences, Ohio University, Athens, Ohio.
Physiology (Bethesda, Md.)
|October 14, 2020
Abstract:
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.

