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Epigenetics and the endocannabinoid system signaling: An intricate interplay modulating neurodevelopment
Telma Marisa Gomes1, Diana Dias da Silva1, Helena Carmo1
1UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal.
Pharmacological Research
|October 14, 2020
Summary
The endocannabinoid system regulates neurodevelopment via epigenetic mechanisms. Disruptions in this interplay may cause neurodevelopmental disorders, highlighting the need to study exogenous cannabinoid impacts.
Area of Science:
- Neuroscience
- Epigenetics
- Developmental Biology
Background:
- The endocannabinoid (eCB) system, comprising eCBs, enzymes, and receptors, is vital for neurodevelopment.
- eCBs influence gene expression through epigenetic actions, affecting neurotransmitter signaling.
- Epigenetic modifications, like DNA methylation and histone modifications, can alter eCB system component function, e.g., CB1R.
Purpose of the Study:
- To review the regulation of neuronal function by the eCB system.
- To examine various epigenetic modifications and their roles.
- To elucidate the interplay between the eCB system and epigenetic mechanisms in neurodevelopment.
Main Methods:
- Literature review of eCB system functions in neurodevelopment.
- Analysis of epigenetic mechanisms (DNA methylation, histone modifications).
- Focus on the interaction between eCB signaling and epigenetic regulation of neurogenesis.
Main Results:
- The eCB system and epigenetic modifications are intricately linked.
- This interaction controls cell fate during neurodevelopment.
- Dysregulation can lead to neurodevelopmental disorders.
Conclusions:
- Understanding the eCB-epigenetic interplay is crucial for neurodevelopmental disorder research.
- Exogenous cannabinoids' epigenetic impact on neurodevelopment requires urgent investigation due to rising usage.
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