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[Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases)]

E A Kogan1, Yu S Berezovsky2, A D Kukleva1

  • 1Sechenov First Moscow State Medical University, Moscow, Russia.

Arkhiv Patologii
|October 15, 2020
PubMed

Insights

This study confirms lymphocytic viral myocarditis can occur in elderly patients with coronavirus disease (COVID-19). Autopsy findings revealed characteristic myocardial inflammation and potential co-occurrence with other cardiac inflammatory conditions.

Area of Science:

  • Cardiology
  • Pathology
  • Infectious Diseases

Background:

  • Myocarditis, inflammation of the heart muscle, is a potential complication of viral infections.
  • Elderly patients with confirmed coronavirus infection present unique challenges for diagnosis and management.

Observation:

  • The study examined four autopsy cases of elderly patients with confirmed coronavirus infection.
  • Morphological and immunohistochemical analyses were conducted on heart specimens to characterize myocardial inflammation and cellular infiltrates.

Findings:

  • Lymphocytic viral myocarditis was morphologically and immunohistochemically confirmed in COVID-19 patients.
  • Key features included the presence of coronaritis (inflammation of coronary arteries) and potential concurrent endo- and pericarditis.

Implications:

  • These findings highlight the importance of considering myocarditis in elderly COVID-19 patients, even in autopsy cases.
  • Understanding the specific features of COVID-19-associated myocarditis can aid in diagnosis and management of cardiac complications.

Keywords:
ACE-2CD3 T lymphocytesCOVID-19SARS-CoV-2TLR-4TLR-9coronavirusendocarditismyocarditisperforin

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