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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

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[Microscopic polyangiitis].

E A Kogan¹, B B Saltykov¹, S G Radenska-Lopovok^1,2

¹Sechenov First Moscow State Medical University, Moscow, Russia.

Arkhiv Patologii

|October 15, 2020

Summary

This autopsy case highlights a fatal outcome in a 69-year-old woman with microscopic polyangiitis, despite aggressive treatment. The study details the extensive vasculitis and organ damage observed, differentiating it from similar conditions.

Keywords:

ANCA-associated vasculitis microscopic polyangiitis morphology

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Published on: October 7, 2018

Area of Science:

Pathology
Rheumatology
Nephrology

Background:

Microscopic polyangiitis is a rare systemic vasculitis.
Early diagnosis and treatment are crucial for patient outcomes.
Understanding morphological variations is key for differential diagnosis.

Observation:

A 69-year-old female patient presented with microscopic polyangiitis.
The condition progressed rapidly over 1.5 months despite intensive therapy.
Autopsy revealed generalized productive vasculitis and extracapillary productive glomerulonephritis.

Findings:

Extensive organ involvement included adult respiratory distress syndrome with pneumonia, splenic infarction, and gangrene of digits.
Morphological analysis distinguished this case from granulomatosis with polyangiitis and Churg-Strauss syndrome.
The autopsy findings underscore the aggressive nature of this vasculitis presentation.

Implications:

This case emphasizes the challenges in treating aggressive microscopic polyangiitis.
Detailed morphological descriptions aid in differentiating vasculitides.
Further research into treatment strategies for severe cases is warranted.