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Plasma renin system during exercise in normal men.

J Staessen, R Fagard, P Hespel

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |July 1, 1987
    PubMed
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    Exercise increases plasma renin activity (PRA), angiotensin II (ANG II), and aldosterone (Aldo). Peak exercise shows a disproportionate rise in ANG II, with aldosterone response varying based on sodium intake and exercise intensity.

    Area of Science:

    • Physiology
    • Endocrinology
    • Exercise Science

    Background:

    • The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and fluid balance.
    • Exercise significantly impacts the RAAS, but the precise responses across varying intensities and sodium levels are complex.

    Purpose of the Study:

    • To investigate the exercise-induced changes in plasma renin activity (PRA), angiotensin II (ANG II), and aldosterone (Aldo) in healthy individuals.
    • To examine how varying exercise intensities and sodium intake influence these hormonal responses.

    Main Methods:

    • Studied 43 healthy volunteers with a wide range of 24-h urinary sodium excretion (UVNa).
    • Collected arterial blood samples at rest and during graded bicycle ergometry (light, moderate, peak, maximal exercise).
    • Measured PRA, ANG II, and Aldo concentrations, correlating them with exercise intensity and UVNa.

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    Main Results:

    • PRA, ANG II, and Aldo increased similarly during light and moderate exercise compared to rest.
    • At peak exercise, ANG II increased significantly more than PRA and Aldo, indicating a steeper ANG II/PRA slope.
    • Aldosterone response to ANG II was attenuated with higher sodium intake (UVNa), and UVNa was negatively correlated with PRA, ANG II, and Aldo independent of exercise.

    Conclusions:

    • Exercise intensity modulates the RAAS response, with ANG II showing a more pronounced increase at peak exertion.
    • Sodium intake significantly influences the aldosterone response to ANG II, suggesting dietary sodium is a key regulator.
    • Higher sodium intake is associated with lower baseline and exercise-induced RAAS activity in healthy individuals.