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Updated: Dec 5, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Ulcerated cutaneous Richter syndrome
Renan Bernardes De Mello1, Everton Carlos Siviero Do Vale
1Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte-Minas Gerais. bernardesrenan@yahoo.com.br.
Abstract:
Richter syndrome or Richter transformation comprises the conversion of chronic lymphocytic leukemia into an aggressive type of large cell lymphoma. Classically, patients have diffuse and abrupt lymphadenopathy and organomegaly, in addition to fever, weight loss, and fatigue. Cutaneous involvement is rare and often nonspecific. We report a patient with chronic lymphocytic leukemia who presented with a large and rapidly evolving ulcer, revealed to be a high-grade cutaneous lymphoma.
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