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Updated: Dec 5, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Ulcerated cutaneous Richter syndrome
Renan Bernardes De Mello1, Everton Carlos Siviero Do Vale
1Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte-Minas Gerais. bernardesrenan@yahoo.com.br.
Richter syndrome, a transformation of chronic lymphocytic leukemia into aggressive lymphoma, rarely presents on the skin. This case highlights a patient whose chronic lymphocytic leukemia progressed to a high-grade cutaneous lymphoma manifesting as a rapidly evolving ulcer.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, typically diffuse large B-cell lymphoma.
- Classical RS symptoms include lymphadenopathy, organomegaly, fever, weight loss, and fatigue.
- Cutaneous involvement in RS is uncommon and often presents with nonspecific signs.
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