Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

304
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
304
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

133
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
133
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

107
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
107
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

240
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
240
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

110
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
110
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

170
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
170

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mouse models to study von Willebrand factor in inflammation: a scoping review.

Intensive care medicine experimental·2026
Same author

Bridging the Gap in Sepsis Recovery: A Scoping Review of Post-Discharge Care Interventions.

Journal of intensive care medicine·2026
Same author

Sepsis policy, guidelines, and standards in Canada: a jurisdictional scoping review.

BMC health services research·2026
Same author

Collecting Accurate and Robust Equity (CARE) data: an analysis of a pilot quality improvement initiative in ambulatory settings.

BMJ open quality·2026
Same author

Factors associated with access to post-sepsis care: a scoping review protocol.

BMJ open·2026
Same author

The SQUEEZE pilot trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid-sparing strategy vs. usual care.

Pilot and feasibility studies·2025
Same journal

Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

Chest·2026
Same journal

Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

Chest·2026
Same journal

Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

Chest·2026
Same journal

How I Do It: De-escalation of Prostacyclin-Based Therapy in Patients Treated With Sotatercept.

Chest·2026
Same journal

Eisenmenger Syndrome: The Pulmonology Perspective.

Chest·2026
Same journal

Phenotyping of pulmonary arterial hypertension associated with congenital heart disease using latent class analysis: insights from a national prospective registry.

Chest·2026
See all related articles

Related Experiment Video

Updated: Dec 5, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

903

Dosing Fluids in Early Septic Shock.

Dipayan Chaudhuri1, Brent Herritt2, Kimberley Lewis1

  • 1Department of Medicine, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.

Chest
|October 15, 2020
PubMed
Summary
This summary is machine-generated.

Optimizing intravenous (IV) fluid administration in sepsis is crucial. This review examines methods to assess fluid responsiveness, guiding appropriate fluid management to improve patient outcomes.

Keywords:
critical care echocardiographyfluid managementsepsisvolume responsive

More Related Videos

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.3K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.9K

Related Experiment Videos

Last Updated: Dec 5, 2025

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

903
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

1.3K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.9K

Area of Science:

  • Critical Care Medicine
  • Emergency Medicine
  • Nephrology

Background:

  • Early intravenous (IV) fluid administration is a cornerstone of sepsis management.
  • Optimal fluid volume, type, and rate remain debated, with risks of over-resuscitation.
  • Overzealous fluid resuscitation can lead to multiorgan failure and prolonged mechanical ventilation.

Purpose of the Study:

  • To review static and dynamic measures for assessing fluid responsiveness in sepsis.
  • To summarize the evidence supporting different fluid responsiveness metrics.
  • To propose a practical approach for evaluating fluid responsiveness in early septic shock.

Main Methods:

  • Literature review of studies on fluid responsiveness assessment in sepsis.
  • Analysis of static and dynamic hemodynamic monitoring techniques.
  • Synthesis of evidence on the efficacy and limitations of various assessment methods.

Main Results:

  • Both static and dynamic measures exist to guide fluid administration.
  • Evidence varies regarding the reliability and clinical utility of different metrics.
  • Individual patient factors and fluid responsiveness measures are key after initial resuscitation.

Conclusions:

  • Assessing fluid responsiveness is essential for tailoring IV fluid therapy in sepsis.
  • Dynamic measures may offer more precise guidance than static measures.
  • Further research is needed to refine fluid management strategies in septic shock.