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Updated: Dec 5, 2025

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Descemetocele.

Rinky Agarwal1, Ritu Nagpal2, Vishnu Todi3

  • 1Senior Resident, Cornea, Cataract and Refractive Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Survey of Ophthalmology
|October 15, 2020
PubMed
Summary
This summary is machine-generated.

A corneal descemetocele, a serious herniation of Descemet membrane, requires urgent intervention to prevent perforation. Management involves prompt medical and surgical options, though optimal strategies remain debated.

Keywords:
AMTDALKPKPcyanoacrylatedellendescemetocelekeratitiskeratomalacia

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Area of Science:

  • Ophthalmology
  • Corneal Disease

Background:

  • A corneal descemetocele is an anterior herniation of Descemet membrane through a stromal defect.
  • It is a rare but serious complication of progressive corneal ulceration, carrying a high risk of perforation.

Purpose of the Study:

  • To review the literature on the pathogenesis, causes, presentation, differential diagnoses, and management of corneal descemetocele.
  • To discuss current treatment strategies and their outcomes.

Main Methods:

  • Literature review of corneal descemetocele management.
  • Analysis of surgical strategies based on descemetocele characteristics.
  • Discussion of clinical experience.

Main Results:

  • Corneal descemetocele can result from microbial keratitis, neurotrophic keratopathy, dry eye, and immune-mediated disorders.
  • Management aims to restore ocular integrity using medical therapy and surgical interventions like grafts, keratoplasty, or conjunctival flaps.
  • Treatment success depends on descemetocele size, location, and etiology.

Conclusions:

  • Prompt intervention is crucial for corneal descemetocele to prevent perforation.
  • A range of medical and surgical options exist, but optimal management strategies require further clarification.
  • Understanding the underlying causes is key to successful treatment.