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Updated: Dec 5, 2025

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Published on: August 29, 2020
Stem cell plasticity and regenerative potential regulation through Ca2+-mediated mitochondrial nuclear crosstalk
Swati Paliwal1, Heather L Fiumera2, Sujata Mohanty3
1Bioscience & Biotechnology Department, Banasthali Vidyapith, Rajasthan 304022, India.
None:
The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is the manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca2+ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca2+ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca2+ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.
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