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Related Experiment Videos

Transgenic livestock.

J P Simons, R B Land

    Journal of Reproduction and Fertility. Supplement
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Transgenic technology allows adding genes to mice, with potential for livestock improvement. Researchers created transgenic mice expressing sheep milk proteins, demonstrating feasibility for altering animal production traits.

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    Area of Science:

    • Genetics
    • Animal Biotechnology
    • Molecular Biology

    Background:

    • Transgenic technology enables routine gene addition in mice, creating 'transgenic' animals.
    • Application in ruminants, like sheep, is limited but shows promise for gene expression.
    • Livestock improvement via transgenesis hinges on identifying traits limited by single protein deficiencies.

    Purpose of the Study:

    • To explore the potential of single dominant gene addition for livestock improvement.
    • To investigate exceptions where single gene alterations may yield favorable effects.
    • To establish a mouse model for studying molecular manipulation of sheep milk proteins.

    Main Methods:

    • Molecular manipulation to add single genes as Mendelian dominants.
    • Incorporation of the sheep beta-lactoglobulin gene into a mouse model.

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  • Utilizing a mouse model to study the expression of foreign genes in mammary glands.

    • Main Results:

    • A mouse model successfully incorporated the sheep beta-lactoglobulin gene.
    • Transgenic mice secreted sheep whey protein from their mammary glands.
    • Demonstrated feasibility of expressing specific animal genes in a heterologous system.

    Conclusions:

    • Transgenic technology offers potential for livestock improvement, particularly for traits influenced by single proteins.
    • Specific gene constructs and promoters can alter protein expression and feedback control.
    • Future directions include gene deletion/reduction and advanced gene incorporation methods, though resource needs are substantial.