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Published on: July 27, 2010
Host Mast Cells in Leishmaniasis: Friend or Foe?
Nilofer Naqvi1, Rahul Srivastava2, Angamuthu Selvapandiyan3
1Cellular and Molecular Immunology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; Present address: ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
Abstract:
Mast cells (MCs) are skin-resident immune cells whose role in leishmaniasis has been recently explored. Researchers report varying inferences, that is, mast cells promote, eliminate, or have no role in leishmaniasis. This article discusses this heterogeneity in mast cell roles to facilitate potential therapeutic and vaccine interventions for these diseases.
