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Updated: Dec 5, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
The Potential of Circular RNAs as Cancer Biomarkers
Jason R Brown1, Arul M Chinnaiyan2
1Rogel Cancer Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Abstract:
Circular RNA (circRNA) is a covalently closed RNA structure that has several proposed functions related to cancer development. Recently, cancer-specific and tissue-specific circRNAs have been identified by high-throughput sequencing and are curated in publicly available databases. CircRNAs have features that are ideal properties of biomarkers, including conservation, abundance, and stability in plasma, saliva, and urine. Many circRNAs with predictive and prognostic significance in cancer have been described, and functional mechanisms for some circRNAs have been suggested. CircRNA also has great potential as a noninvasive biomarker for early cancer detection, although further investigation is necessary before clinical application is feasible.See all articles in this
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