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Updated: Dec 5, 2025

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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Circular RNAs and Bladder Cancer.

Zhonglin Cai1, Hongjun Li1

  • 1Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Oncotargets and Therapy
|October 16, 2020
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are key regulators in bladder cancer (BC) development. This review explores how circRNAs influence BC

Keywords:
biomarkerbladder cancercircRNAmiRNA

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer (BC) is a prevalent urinary system malignancy posing significant health risks.
  • Circular RNAs (circRNAs), a class of noncoding RNAs (ncRNAs), regulate gene expression post-transcriptionally.
  • circRNAs are implicated in BC's clinicopathological features, prognosis, and treatment response.

Purpose of the Study:

  • To review the association between circRNAs and clinical characteristics of BC.
  • To explore the molecular mechanisms by which circRNAs drive tumor progression in BC.

Main Methods:

  • Literature review of studies on circRNAs and bladder cancer.
  • Analysis of molecular mechanisms involving circRNAs, microRNAs (miRNAs), and signaling pathways.

Main Results:

  • circRNAs influence BC progression through interactions with miRNAs.
  • They regulate transcription factors and both classical and nonclassical tumor signaling pathways.
  • Nonclassical pathways affected include cell cycle, epithelial-mesenchymal transition (EMT), and tumor stemness.

Conclusions:

  • circRNAs play a crucial role in the biological functions and development of bladder cancer.
  • Understanding circRNA mechanisms offers potential therapeutic targets for BC.