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Updated: Jun 9, 2025

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
Recent advances in bacteria-based platforms for inflammatory bowel diseases treatment
Jiaoying Lu1, Xinyuan Shen2,3, Hongjun Li2,4,5
1Department of Gastroenterology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China.
Abstract:
Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and are associated with gastrointestinal or systemic adverse effects. New delivery strategies are needed for the treatment of IBD. Bacteria are promising biocarriers, which can produce drugs in situ and sense the gut in real time. Herein, we focus on recent studies of engineered bacteria used for IBD treatment and introduce the application of engineered bacteria in the diagnosis. On this basis, the current dilemmas and future developments of bacterial delivery systems are discussed.
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