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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...

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Updated: Jun 19, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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What can microfluidics do for human microbiome research?

Hsih-Yin Tan1, Yi-Chin Toh

  • 1Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599.

Biomicrofluidics
|October 16, 2020
PubMed
Summary
This summary is machine-generated.

Microfluidic technologies offer innovative solutions for human microbiome research, enabling advancements in diagnostics and therapeutics by overcoming challenges in sample processing and functional analysis.

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Area of Science:

  • Microbiome research
  • Microfluidics
  • Biotechnology

Background:

  • Human microbiome dysregulation is linked to diseases, driving research to modulate health via microbial communities.
  • Current microbiome research progresses through identification, association, causation, and translation phases.
  • Conventional methods face challenges in microbiome research.

Purpose of the Study:

  • To explore the application of microfluidic technologies in microbiome research.
  • To identify opportunities and challenges of microfluidics in microbiome studies.
  • To discuss microfluidics' role in advancing microbiome-based diagnostics and therapeutics.

Main Methods:

  • Review of microfluidic applications in microbiome research.
  • Discussion of integrated microfluidic systems for genomic sequencing.
  • Coverage of microfluidic devices for microbiota cultivation and functional measurements.
  • Highlighting organ-on-chip models for microbiome-host interactions.

Main Results:

  • Microfluidics can address challenges in sample processing for genomic analysis.
  • Novel microfluidic devices facilitate microbiota cultivation and functional assessments.
  • Organ-on-chip systems enable modeling of microbiome-host tissue dynamics.

Conclusions:

  • Microfluidic technologies show significant promise for advancing microbiome research.
  • These technologies can accelerate the translation of microbiome knowledge into clinical applications.
  • Microfluidics offers a powerful platform for understanding microbiome-human health interplay.