Related Experiment Video

Updated: Dec 5, 2025

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

4.4K

Establishment of Pediatric Reference Intervals for Routine Laboratory Tests in Korean Population: A Retrospective

Ji Yeon Sung1, Jong Do Seo1, Dae-Hyun Ko2

  • 1Department of Laboratory Medicine, Seoul National University Hospital and College of Medicine, Seoul, Korea.

Annals of Laboratory Medicine
|October 16, 2020
PubMed

Insights

New reference intervals for Korean pediatric patients were established for common lab tests. These findings are crucial for accurate clinical evaluations in this specific population.

Area of Science:

  • Clinical Chemistry
  • Pediatric Hematology
  • Laboratory Medicine

Background:

  • Established reference intervals for adults or other ethnicities are unsuitable for Korean pediatric patients.
  • Pediatric reference intervals are challenging due to continuous physiological changes during growth.
  • This study aimed to establish specific reference intervals for Korean children.

Purpose of the Study:

  • To establish age- and sex-specific reference intervals for routine laboratory tests in Korean pediatric patients.
  • To provide accurate diagnostic benchmarks for the Korean pediatric population.
  • To address the limitations of applying non-native reference intervals.

Main Methods:

  • Retrospective analysis of preoperative laboratory test results from 1,031 pediatric patients (0-18 years).
  • Data collected from four university hospitals.
  • Reference intervals determined using Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines.

Main Results:

  • Established Korean pediatric reference intervals differ significantly from adult and other ethnic pediatric intervals.
  • Most laboratory tests required age-specific partitioning.
  • Some tests also necessitated sex-specific partitioning within age groups.

Conclusions:

  • Korean pediatric reference intervals for hematology, coagulation, and chemistry tests were successfully determined.
  • These intervals were established using indirect sampling from multi-institutional medical records.
  • The derived reference intervals are valuable for clinical decision-making in Korean children.
Abstract

Keywords:
Age-partitioned groupsIndirect samplingKorean pediatricsMulticenterReference intervalsSex-partitioned groups

More Related Videos

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.5K
Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children06:22

Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children

Published on: February 10, 2023

1.2K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
127
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
159
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
105
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
138
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
133
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
73