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Single-institutional reference values for concentric needle jitter analysis using the extrapolated reference values

Ikjae Lee1, Donald B Sanders2, Sanjeev D Nandedkar3

  • 1Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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|October 16, 2020
PubMed
Summary
This summary is machine-generated.

The extrapolated reference values (E-Ref) procedure for concentric needle jitter provides results comparable to established reference values (RV). This method validates single-institution data against broader norms for jitter analysis.

Keywords:
EMGSFEMGconcentric needlejittermyasthenia gravisreference values

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Area of Science:

  • Neurology
  • Electromyography

Background:

  • Concentric electrode jitter analysis is crucial for diagnosing neuromuscular disorders.
  • Established reference values (RV) for jitter are essential for accurate interpretation.
  • Single-institution data requires validation against broader norms.

Purpose of the Study:

  • To compare single-institution concentric needle jitter data with recently published reference values (RV).
  • To evaluate the efficacy of the extrapolated reference values (E-Ref) procedure in establishing institution-specific jitter cutoffs.

Main Methods:

  • Retrospective chart review of voluntarily activated concentric needle jitter studies in the frontalis muscle.
  • Application of the E-Ref procedure to calculate cutoff values for increased jitter.
  • Comparison of E-Ref derived cutoff values with published RVs.

Main Results:

  • A total of 1371 acceptable apparent single-fiber action potential (ASFAP) pairs were analyzed.
  • E-Ref identified cutoff values of 36 µs (all pairs) and 35 µs (acceptable pairs).
  • No significant difference was observed in the percentage of normal jitter recordings compared to the published RV of 38 µs.

Conclusions:

  • The E-Ref procedure yields single-institution jitter cutoff values that are not significantly different from established RVs.
  • E-Ref offers a reliable method for validating and normalizing single-institution jitter data.
  • This approach supports consistent diagnostic interpretation of concentric needle jitter across different centers.