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Biotherapeutic Products, Cellular Factories, and Multiomics Integration in Metabolic Engineering
Nguyen Hoang Anh1, Jung Eun Min1, Sun Jo Kim1
1College of Pharmacy, Seoul National University, Seoul, South Korea.
Abstract:
Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology, and machine learning/artificial intelligence are expected to introduce innovative solutions in every aspect of the mammalian cell culture-based biotherapeutic production. This conceptual review offers a synthesis of the prospects and challenges of integration of multiomics technologies, and an integrative biology vision to cellular factories and biotherapeutic innovation.
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