Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Control of neuron shape during development and regeneration.

M J Cohen, G F Hall

    Neurochemical Pathology
    |December 1, 1986
    PubMed
    Summary

    Injury to Mueller neurons in larval sea lamprey CNS can trigger regenerative sprouting. Axotomy near the cell body causes dendritic sprouting, mimicking axonal regeneration and suggesting recapitulation of embryonic development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dramatically improved hand hygiene performance rates at time of coronavirus pandemic.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
    Same author

    A simplified blood culture sampling protocol for reducing contamination and costs: a randomized controlled trial.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    Measles-related hospitalizations and associated complications in Jerusalem, 2018-2019.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    Procalcitonin in hemodialysis patients presenting with fever or chills to the emergency department.

    Internal and emergency medicine·2019
    Same author

    Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy.

    Clinical and experimental immunology·2018
    Same author

    Predictors for Adherence to Multidisciplinary Follow-Up Care after Sleeve Gastrectomy.

    Obesity surgery·2018

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Regenerative Medicine

    Background:

    • Mueller cells are crucial for neuronal function and regeneration in the central nervous system (CNS).
    • Understanding neuronal injury response is key to advancing regenerative strategies.

    Purpose of the Study:

    • To investigate the regenerative sprouting capacity of Mueller reticulospinal neurons following axonal and dendritic injury in larval sea lamprey.
    • To determine the specific requirements for sprouting and the influence of injury location.

    Main Methods:

    • Axotomy and dendrotomy of Mueller cells in the larval sea lamprey CNS.
    • Microscopic analysis of neuritic sprouting patterns and morphology.
    • Observation of sprout trajectories and growth cone formation.

    Main Results:

    • Axotomy distant from the soma induced axonal sprouting.
    • Axotomy near the soma triggered profuse dendritic sprouting with axonal-like morphology.
    • Dendrotomy alone did not induce sprouting, but could alter sprouting patterns in previously axotomized cells.
    • Sprouts followed linear paths along the ventral hindbrain, with some forming large growth cones.

    Conclusions:

    • Axotomy is a specific trigger for regenerative sprouting in Mueller neurons.
    • Dendritic sprouting can functionally mimic axonal regeneration.
    • Sprout trajectories may be guided by persistent developmental cues in the ventral hindbrain, suggesting recapitulation of embryogenesis.

    Related Experiment Videos