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The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function
1Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
Cell Chemical Biology
|October 16, 2020
Abstract:
Cell permeable, small molecule inhibitors are powerful tools for interrogating kinase function and validating drug targets. In this issue of Cell Chemical Biology, Liu and colleagues (2020) describe the development of a toolkit containing a highly selective DCLK1 inhibitor and complementary DCLK1 mutants for interrogating DCLK1-dependent cellular processes.
