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Updated: Dec 5, 2025

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
Cortical circuits for transforming whisker sensation into goal-directed licking
Vahid Esmaeili1, Keita Tamura1, Georgios Foustoukos1
1Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
Abstract:
Animals can learn to use sensory stimuli to generate motor actions in order to obtain rewards. However, the precise neuronal circuits driving learning and execution of a specific goal-directed sensory-to-motor transformation remain to be elucidated. Here, we review progress in understanding the contribution of cortical neuronal circuits to a task in which head-restrained water-restricted mice learn to lick a reward spout in response to whisker deflection. We first examine 'innate' pathways for whisker sensory processing and licking motor control, and then discuss how these might become linked through reward-based learning, perhaps enabled by cholinergic-gated and dopaminergic-gated plasticity. The aim is to uncover the synaptically connected neuronal pathways that mediate reward-based learning and execution of a well-defined sensory-to-motor transformation.
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