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[Importance of HLA systems in the regulation of hematopoiesis]
Human hematopoiesis is known to be influenced by local microenvironments, as well as by a large number of specific soluble inhibitory or stimulatory mediators. It has been suggested that the HLA system plays an important role in the regulation of physiological and pathological hematopoietic cell proliferation and differentiation. The quality and quantity of HLA-antigen expression have been shown to influence interactions of colony-inhibitory factors with hematopoietic precursor cells. It is also assumed that HLA antigens mediate regulatory mechanisms of T-lymphocytes on the production of hematopoietic factors, as well as on hematopoietic cell proliferation and differentiation. The HLA antigens may thus participate in regulatory functions of the immune system in hematopoiesis.
Human hematopoiesis is known to be influenced by local microenvironments, as well as by a large number of specific soluble inhibitory or stimulatory mediators. It has been suggested that the HLA system plays an important role in the regulation of physiological and pathological hematopoietic cell proliferation and differentiation. The quality and quantity of HLA-antigen expression have been shown to influence interactions of colony-inhibitory factors with hematopoietic precursor cells. It is also assumed that HLA antigens mediate regulatory mechanisms of T-lymphocytes on the production of hematopoietic factors, as well as on hematopoietic cell proliferation and differentiation. The HLA antigens may thus participate in regulatory functions of the immune system in hematopoiesis.