[Observation on the Thrombus Formation in Real Time in Vivo by using High-Resolution Confocal Microscope Combined...

The process of thrombus formation in vivo is complex, which is affected by the platelets, clotting system, and vessels, as well as blood flow. The previous research ways, which were either static or shear stress-mimicking ex vivo, could not reflect the condition in vivo completely. In recent years, The high resolution confocal microscope combined with bioluminescence system was developed which can be used to observe the animal thrombus formation in real time in vivo. By using this system, scientists have gotten a novel knowledge about the thrombus formation. In this review, the operating steps of this system, the hierarchical structure of thrombs revealed by this system and the related mechanism are sammrized briefly.