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Updated: Dec 5, 2025
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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
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Update on extracranial arteriovenous malformations: A staged multidisciplinary approach
Mary Roz Timbang1, Gresham T Richter1
1University of Arkansas for Medical Sciences, Arkansas Children's Hospital, 1 Children's Way, Slot 836, Little Rock, AR 72202, United States.
Seminars in Pediatric Surgery
|October 18, 2020
Summary
Arteriovenous malformations (AVMs) are abnormal vascular connections. New insights into their causes guide improved, multidisciplinary treatments for peripheral AVMs, enhancing patient outcomes.
Area of Science:
- Vascular Biology
- Medical Science
Background:
- Arteriovenous malformations (AVMs) are congenital vascular lesions with abnormal artery-vein connections.
- While often in the brain, peripheral AVMs occur in the head, neck, and limbs, infiltrating soft tissues.
Purpose of the Study:
- To review current treatment approaches for extracranial AVMs.
- To highlight how understanding AVM etiology and physiology informs management.
Main Methods:
- Review of current literature on peripheral AVMs.
- Discussion of multimodal and multidisciplinary treatment strategies.
- Integration of new genetic and pharmacologic insights.
Main Results:
- Peripheral AVMs require selective treatment preserving surrounding tissues.
- Staged, multimodal approaches combining various techniques are optimal.
- Somatic and germline mutations are identified, leading to new pharmacologic treatments.
Conclusions:
- A comprehensive understanding of AVM pathophysiology is crucial for effective management.
- Adjuvant medical therapy shows promise in enhancing interventional and surgical outcomes.
- Multidisciplinary, staged treatment plans are essential for managing peripheral AVMs.
