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Related Experiment Videos

Captopril-induced liver dysfunction.

N Tabibian, L Alpert, E Alpert

    Southern Medical Journal
    |September 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Captopril medication can cause cholestatic jaundice, a rare liver condition. Discontinuing captopril rapidly resolves the jaundice, confirming it as the cause.

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    Area of Science:

    • Hepatology
    • Pharmacology

    Background:

    • Cholestatic jaundice is a liver condition characterized by impaired bile flow.
    • Drug-induced liver injury (DILI) is a significant concern in clinical practice.

    Observation:

    • A patient presented with symptoms of cholestatic jaundice.
    • The patient was administered captopril, an angiotensin-converting enzyme (ACE) inhibitor.

    Findings:

    • Captopril was identified as the causative agent for the patient's cholestatic jaundice.
    • Jaundice resolved promptly upon cessation of captopril therapy, confirming causality.

    Implications:

    • This case highlights the potential hepatotoxicity of captopril.
    • Clinicians should consider captopril-induced cholestatic jaundice in patients presenting with these symptoms.
  • Awareness of this adverse effect is crucial for patient safety and effective management.