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Published on: May 13, 2018
Lubrication empirical model to predict tensile strength of directly compressed powder blends
Joelle Nassar1, Ben Williams2, Conrad Davies3
1GSK, Park Rd, Ware SG12 0DP, United Kingdom.
Abstract:
A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a pre-requisite for simulation of the compaction unit operation where a linkage from tablet press operating parameters and formulation material properties to output tensile strength is required. The approach extends the previously published Kushner and Moore model to allow calculation across a range of solid fractions. The applicability of the approach is supported by testing using formulations with different commonly used pharmaceutical excipients.
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