Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

8.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.3K
Structure and Function of Platelets01:18

Structure and Function of Platelets

2.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.5K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

910
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
910
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.3K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Biological and Psychological Profiles of Hospital Healthcare Professionals During a Stressful Wartime.

Journal of general internal medicine·2026
Same author

Workability and Biological Biomarkers of Hospital Professionals during War.

QJM : monthly journal of the Association of Physicians·2026
Same author

Artificial intelligence improved efficiency of the computed tomography program.

Irish journal of medical science·2026
Same author

Endothelial function and cardiovascular disease in patients with rheumatoid arthritis.

Polish archives of internal medicine·2025
Same author

Sleep Deprivation and Endothelial Function.

The Israel Medical Association journal : IMAJ·2025
Same author

[CAN WE USE ASPIRIN AS A PRIMARY PREVENTION FOR CARDIOVASCULAR DISEASE?]

Harefuah·2025

Related Experiment Video

Updated: Dec 5, 2025

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

2.8K

Platelets and Breast Cancer.

Naama Garmi1, Suheil Nasrallah1,2, Yacov Baram2

  • 1Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.

The Israel Medical Association Journal : IMAJ
|October 18, 2020
PubMed
Summary

Elevated platelet counts may indicate a higher risk of breast cancer progression. Lower pre-treatment platelet counts were associated with poorer outcomes in patients with breast cancer.

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

897
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.3K

Related Experiment Videos

Last Updated: Dec 5, 2025

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

2.8K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

897
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.3K

Area of Science:

  • Oncology
  • Hematology
  • Cancer Research

Background:

  • Thrombocytosis, or elevated platelet counts, has been linked to the development of various cancers.
  • Understanding the role of platelets in cancer progression is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the correlation between pre-treatment platelet counts and clinical outcomes in breast cancer patients.
  • To determine if platelet counts serve as a prognostic marker in breast cancer.

Main Methods:

  • A retrospective study analyzed clinical and hematological data from 53 breast cancer patients across different stages (I-IV).
  • Patient data included platelet counts, age, lymph node status, and white blood cell counts.
  • Follow-up ranged from 12 months to 5 years.

Main Results:

  • Significant differences in platelet counts were observed between patients who died and those who achieved 5-year disease-free survival (P=0.0001).
  • Platelet-to-lymphocyte ratio differed significantly between patients who died and those with recurrence (P=0.01).
  • Positive correlations were found between clinical staging and lymph nodes (P=0.001) and staging and metastases (P=0.02).

Conclusions:

  • Pre-treatment platelet counts may serve as a prognostic indicator for breast cancer.
  • Lower platelet counts in patients who died within one year suggest a potential link to cancer-related consumption processes.