The m6A epitranscriptome opens a new charter in immune system logic.

Area of Science:

• Immunology
• Molecular Biology
• Epigenetics

Background:

• N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes and prokaryotes.
• The m6A epitranscriptome significantly influences immune response and function.
• Recent advances have elucidated the mechanisms of m6A modification in the immune system.

Purpose of the Study:

• To systematically review the role of m6A modification in regulating innate and adaptive immune cells.
• To comprehensively summarize the interplay between m6A and anti-inflammatory, anti-viral, and anti-tumour immunity.
• To discuss future prospects of m6A modification in immune modulation.

Main Methods:

• Systematic literature review.
• Analysis of existing studies on m6A modification and immune system interactions.
• Synthesis of current knowledge on m6A's role in various immune responses.

Main Results:

• m6A modification is involved in the regulation of both innate and adaptive immune cells.
• m6A plays a crucial role in anti-inflammatory, anti-viral, and anti-tumour immune responses.
• The review consolidates the complex interactions between m6A and immune functions.

Conclusions:

• A deeper understanding of the m6A epitranscriptome's impact on immunity is essential.
• m6A modification offers potential as a therapeutic target for various diseases.
• Further research into the m6A-immune system crosstalk can reveal novel pathogenic pathways.