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Related Concept Videos

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Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
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Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Enhancing Cerebral Ischemia Research with a Simplified Rat Model
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Locked-In with COVID-19.

Akshay Avula1, Arshpal Gill2, Ra'ed Nassar2

  • 1Department of Pulmonary Critical Care Medicine, Northwell Health - Staten Island University Hospital, NY, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|October 19, 2020
PubMed
Summary
This summary is machine-generated.

A COVID-19 cytokine storm led to pontine strokes and Locked-In Syndrome in a young patient. This case highlights the critical need for rapid diagnosis and treatment of neurological complications during the pandemic.

Keywords:
COVID-19HypercoagulabilityLocked in SyndromeStroke

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus Disease 2019 (COVID-19) presents diverse neurological complications, including acute strokes.
  • The pandemic strains healthcare systems, creating barriers to timely stroke diagnosis and treatment.
  • Delayed patient presentation and healthcare professional shortages exacerbate stroke management challenges.

Observation:

  • Literature indicates an association between COVID-19 and acute strokes in young individuals.
  • Diagnosing neurological conditions in intensive care unit patients is complex due to factors like sedation and encephalopathy.
  • Locked-In Syndrome (LIS), characterized by immobility and preserved consciousness, poses diagnostic difficulties.

Findings:

  • This report details a 25-year-old patient with no prior coagulopathy who developed a COVID-19 cytokine storm.
  • The cytokine storm resulted in pontine strokes, leading to Locked-In Syndrome.
  • The case underscores the potential for severe neurological outcomes in young COVID-19 patients.

Implications:

  • Early recognition and management of neurological manifestations in COVID-19 are crucial for improving patient outcomes.
  • Understanding the pathophysiology of COVID-19-associated neurological events is essential.
  • This case emphasizes the importance of considering rare but severe complications like LIS in young patients with COVID-19.