Cardiovascular Risk and Comorbidities in Patients with Rosacea: A Systematic Review and Meta-analysis
Tsung-Yu Tsai1, Ying-Yi Chiang, Yu-Chen Huang
1Department of Dermatology, Wan Fang Hospital, Taipei Medical University, 111, Hsing-Long Road Sec. 3, Wenshan District, Taipei City 116, Taiwan.
Patients with rosacea have increased cardiovascular risk factors, including higher blood pressure and cholesterol. This suggests rosacea may predispose individuals to subclinical cardiovascular disease.
Area of Science:
- Dermatology
- Cardiology
- Epidemiology
Background:
- The link between rosacea and cardiovascular disease (CVD) is debated.
- Previous studies have yielded conflicting results regarding this association.
Purpose of the Study:
- To systematically review and analyze existing literature.
- To compare cardiovascular risk and comorbidities in individuals with and without rosacea.
Main Methods:
- A systematic review and meta-analysis of studies published up to February 15, 2020.
- Inclusion of twelve studies encompassing 40,752 patients with rosacea.
Main Results:
- Patients with rosacea exhibited elevated systolic and diastolic blood pressure.
- Increased total cholesterol, low-density lipoprotein, and C-reactive protein levels were observed.
- Greater epicardial fat thickness, higher incidence of hypertension, and insulin resistance were noted in rosacea patients.
Conclusions:
- Rosacea is associated with increased subclinical cardiovascular risk.
- Findings suggest a predisposition to cardiovascular complications in individuals with rosacea.
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