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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

3.8K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: Sep 29, 2025

Enrichment and Purging of Human Embryonic Stem Cells by Detection of Cell Surface Antigens Using the Monoclonal Antibodies TG30 and GCTM-2
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Enrichment and Purging of Human Embryonic Stem Cells by Detection of Cell Surface Antigens Using the Monoclonal Antibodies TG30 and GCTM-2

Published on: December 6, 2013

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Requirements for human embryonic stem cells.

Jie Hao1,2, Jiani Cao1,2, Lei Wang1,2

  • 1State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, National Stem Cell Resource Center, Chinese Academy of Sciences, Beijing, China.

Cell Proliferation
|October 19, 2020
PubMed
Summary
This summary is machine-generated.

China has released the first national guidelines for human embryonic stem cells (hESCs). These standards ensure quality control for hESCs, covering technical requirements, testing, and handling, promoting international standardization.

Keywords:
human embryonic stem cellsquality controlstandard

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Area of Science:

  • Stem Cell Research
  • Biotechnology Standards
  • Regenerative Medicine

Background:

  • Human embryonic stem cells (hESCs) hold significant therapeutic potential.
  • Lack of standardized protocols has hindered consistent research and clinical application of hESCs.
  • Establishing national guidelines is crucial for quality control and safety in hESC research.

Purpose of the Study:

  • To introduce the first set of national guidelines for human embryonic stem cells in China.
  • To establish comprehensive standards for the quality control of hESCs.
  • To promote the acceptance and execution of proper protocols in hESC research and applications.

Main Methods:

  • Jointly drafted by experts from the Chinese Society for Stem Cell Research.
  • Specifies technical requirements, test methods, and regulations.
  • Includes guidelines for labeling, packaging, storage, and transportation.

Main Results:

  • Publication of 'Requirements for Human Embryonic Stem Cells' (first edition released Feb 2019, revised Apr 2020).
  • Provides a framework for consistent quality control of hESCs.
  • Aims to facilitate institutional adoption of standardized hESC protocols.

Conclusions:

  • These guidelines represent a significant step towards the standardization of hESC research and applications in China.
  • The established standards are expected to accelerate international harmonization of hESC protocols.
  • Promoting consistent quality and safety measures for hESCs is vital for advancing regenerative medicine.