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Published on: July 14, 2020
Operative Technique and Lessons Learned From Surgical Implantation of the NeuroPace Responsive Neurostimulation®
Max O Krucoff1,2, Thomas A Wozny1, Anthony T Lee1
1Department of Neurosurgery, University of California, San Francisco, San Francisco, California.
Background:
The Responsive Neurostimulation (RNS)® System (NeuroPace, Inc) is an implantable device designed to improve seizure control in patients with medically refractory focal epilepsy. Because it is relatively new, surgical pearls and operative techniques optimized from experience beyond a small case series have yet to be described.
Objective:
To provide a detailed description of our operative technique and surgical pearls learned from implantation of the RNS System in 57 patients at our institution. We describe our method for frame-based placement of amygdalo-hippocampal depth leads, open implantation of cortical strip leads, and open installation of the neurostimulator.
Methods:
We outline considerations for patient selection, preoperative planning, surgical positioning, incision planning, stereotactic depth lead implantation, cortical strip lead implantation, craniotomy for neurostimulator implantation, device testing, closure, and intraoperative imaging.
Results:
The median reduction in clinical seizure frequency was 60% (standard deviation 63.1) with 27% of patients achieving seizure freedom at last follow up (median 23.1 mo). No infections, intracerebral hemorrhages, or lead migrations were encountered. Two patients experienced lead fractures, and four lead exchanges have been performed.
Conclusion:
The techniques set forth here will help with the safe and efficient implantation of these new devices.
