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Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds
Alexandra Borges1, Victor de Freitas1, Nuno Mateus1
1LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, S/N, 4169-007 Porto, Portugal.
Antioxidants (Basel, Switzerland)
|October 20, 2020
Summary
Nanotechnology, using lipidic systems like solid lipid nanoparticles and nanostructured lipid carriers, enhances the bioavailability and stability of natural phenolic compounds for cosmetic and pharmaceutical use.
Area of Science:
- Natural Product Chemistry
- Nanotechnology
- Drug Delivery Systems
Background:
- Phenolic compounds possess significant antioxidant and anticancer properties, valuable for chronic disease prevention and treatment.
- Low bioavailability and instability (pH, temperature, light) limit the therapeutic application of natural phenolics.
- Nanotechnology offers solutions to overcome these limitations in drug delivery.
Purpose of the Study:
- To review the role of nanotechnology, specifically lipidic encapsulation systems, in enhancing phenolic compound bioavailability and stability.
- To explore preparation methods and functionalization of lipidic nanoparticles for phenolic compounds.
- To discuss potential applications of these advanced systems in cosmetic and pharmacologic products.
Main Methods:
- Review of scientific literature on lipidic nanoparticles for phenolic compound delivery.
- Analysis of preparation techniques for solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs).
- Examination of functionalization strategies to improve nanoparticle performance.
Main Results:
- Solid lipid nanoparticles and nanostructured lipid carriers effectively protect phenolic compounds from degradation.
- These lipidic systems significantly improve the bioavailability of encapsulated phenolics.
- Functionalization approaches further enhance stability and targeted delivery.
Conclusions:
- Lipidic nanoparticles represent a promising strategy to enhance the stability and bioavailability of natural phenolic compounds.
- These systems hold potential for developing novel cosmetic and pharmaceutical products with improved efficacy.
- Further research into preparation and functionalization can optimize phenolic compound delivery.
Keywords:
bioactivitychemical stabilizationnanostructured lipid carriersphenolic compoundssolid lipid nanoparticlesMore Related Videos
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