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Evaluation of human brain hyperthermia using exergy balance equation
Imran Mahmood1, Ali Raza1, Aamir Mehmood2
1Department of Mechatronics & Control Engineering, University of Engineering and Technology, Lahore, 54890, Pakistan.
Journal of Thermal Biology
|October 20, 2020
Summary
This study models hyperthermia thresholds using human-body exergy balance, providing critical ranges for rehabilitation therapy. The exergy-based approach effectively models thermal trauma at pathophysiological boundaries.
Area of Science:
- Thermodynamics
- Human Physiology
- Biomedical Engineering
Background:
- Hyperthermia, a thermoregulatory disturbance, necessitates emergency treatment to prevent severe outcomes.
- Designing therapeutic devices for hyperthermia requires understanding the limits of thermal trauma.
- Existing models for hyperthermia are often limited to the physiological domain.
Purpose of the Study:
- To establish hyperthermia thresholds using an exergy-balance equation for the human body.
- To pioneer a model for hyperthermia states by evaluating metabolic heat generation and related parameters.
- To provide guidelines for rehabilitation therapy by analyzing critical ranges of thermal conditions.
Main Methods:
- Incorporation of the human-body exergy-balance equation to compute hyperthermia thresholds.
- Utilizing an induced-hyperthermia technique to assess metabolic heat generation extremes.
- Calculating exergy consumption (EC) and entropy generation rate (δSg) in a case study.
- Simulating thresholds under varying body and environmental conditions.
- Developing a thermal manikin with simulated blood circulation to validate the exergy approach.
Main Results:
- The study successfully computed hyperthermia thresholds using the exergy-balance equation.
- Exergy consumption (EC) and entropy generation rate (δSg) were calculated to define thermal energy maxima.
- Simulations identified critical ranges for hyperthermia under diverse conditions.
- The thermal manikin results substantiated the efficacy of the exergy-based approach.
- The exergy-based approach demonstrated suitability for modeling hyperthermia at pathophysiological boundaries.
Conclusions:
- The exergy-based approach offers a robust method for modeling hyperthermia, extending beyond the physiological domain.
- This research provides crucial insights into thermal trauma extremes, aiding in the design of therapeutic interventions.
- The established critical ranges offer valuable guidelines for hyperthermia rehabilitation therapy.
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