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Mechanisms of COVID-19-induced cardiovascular disease: Is sepsis or exosome the missing link?

Mallikarjun Patil1, Sarojini Singh1, John Henderson1

  • 1Department of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Journal of Cellular Physiology
|October 20, 2020
PubMed

Insights

This review explores severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its link to cardiac injury. It discusses potential therapeutic strategies, including targeting exosomes for COVID-19 symptoms.

Area of Science:

  • Virology
  • Cardiology
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic with significant mortality.
  • The virus's high infectivity and limited understanding of its immunogenicity and molecular targets pose challenges.
  • Cardiac injury is a recognized complication of COVID-19, but its pathogenesis remains unclear.

Purpose of the Study:

  • To review the SARS-CoV-2 virus and its mechanisms.
  • To discuss COVID-19-induced cardiac injury pathogenesis.
  • To explore potential therapeutic strategies, including exosome-based treatments and understanding virus-induced sepsis.

Main Methods:

  • Literature review on SARS-CoV-2.
  • Analysis of COVID-19 pathogenesis and cardiac injury mechanisms.
  • Exploration of exosome therapy and sepsis in COVID-19.

Main Results:

  • SARS-CoV-2 is highly infectious, contributing to its rapid global spread.
  • Cardiac injury is a significant concern in COVID-19 patients.
  • Virus-induced sepsis may contribute to multi-organ failure, including myocardial injury.

Conclusions:

  • Further research is needed to fully understand SARS-CoV-2 pathogenesis and its cardiac implications.
  • Exosomes present a potential therapeutic avenue for managing COVID-19 symptoms.
  • Addressing virus-induced sepsis is crucial for mitigating multi-organ failure in COVID-19.

Keywords:
COVID-19SARS-CoV-2cardiovascular diseaseexosomessepsis

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